How do cells move, sense their environment, and adapt their behaviour?
This question sits at the heart of some of biology’s most consequential processes: tumour metastasis, angiogenesis, and embryogenesis.
And answering it requires connecting molecular-scale mechanics to large-scale computational simulation.
In the third dealiiX seminar, Prof. Alberto Salvadori and Mattia Serpelloni (Università degli Studi di Brescia, Mechanobiology Research Center) presented a continuum multiphysics framework for cell locomotion, covering the engine, the adhesion, and the active relocation of integrins during migration.
Central to their talk: how integrin mobility within the lipid bilayer drives the transition from transient adhesion contacts to stable focal adhesions, and how HPC simulations via deal.II capture integrin redistribution during membrane advection, benchmarked against experimental data.
Seminar Recording
(first few minutes are cut off due to a technical issue, we apologise for that)
A valuable exchange for the community
The seminar brought together researchers working in computational modelling, numerical methods, and high-performance computing, fostering an engaging discussion on state-of-the-art approaches for exascale-ready simulations.
We would like to thank Prof. Alberto Salvadori and Mattia Serpelloni for the excellent presentation and all participants for their active engagement.
Stay tuned for upcoming dealiiX seminars and events, as we continue to explore advanced methods and technologies shaping the future of scientific computing.